PhD Scientific Days 2026

Conservative Medicine

Psoriasis and Cardiovascular Adverse Events During Biologic Therapy: A Systematic Review and Meta-Analysis

Előadó neve

Dr. Kolonics, Mária Veronika

Neptune code

C0CJX4

Előadó munkahelye

Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Centre for Translational Medicine, Semmelweis University

Előadó telefonszáma

+36309776619

Előadó e-mail címe

mv.kolonics@gmail.com

Az előadás címe

Psoriasis and Cardiovascular Adverse Events During Biologic Therapy: A Systematic Review and Meta-Analysis

Szerző(k) neve és munkahelye

Mária Veronika Kolonics¹, Katalin Martyin¹, Noémi Ágnes Galajda¹, Fanni Adél Meznerics¹, Adib Abed¹, Karen Krisztina Fazekas², Máté Krebs¹, Ákos Ungvári¹, Anna Czibulya¹, Péter Kulyassa³, Lajos Vince Kemény¹, Norbert Kiss¹, Péter Hegyi⁴, András Bánvölgyi¹, Péter Holló⁵

1: Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, Centre for Translational Medicine, Semmelweis University
2: Centre for Translational Medicine, Semmelweis University
3: Heart and Vascular Centre, Semmelweis University, Centre for Translational Medicine, Semmelweis University
4: Centre for Translational Medicine, Semmelweis University, Institute of Pancreatic Diseases, Semmelweis University
5: Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University

Bemutatás módja

Szóbeli

Szekció

Conservative Medicine

Language of the presentation

English

Preferred session

Conservative Medicine

Összefoglaló szövege

Introduction:
Psoriasis is linked to elevated cardiovascular (CV) morbidity, which may complicate treatment decisions. Although biologics are highly effective, concerns about rare but serious CV events may still influence prescribing and patient acceptance.
Aims:
To summarize evidence on serious CV outcomes reported during biologic therapy in psoriasis.
Method:
A systematic review identified randomized and non-randomized interventional studies and longitudinal observational cohorts on TNF, IL-12/23, IL-17, and IL-23 inhibitors in psoriasis. Prespecified outcomes were major adverse cardiovascular events (MACE), myocardial infarction, ischemic stroke, CV death, and heart failure. Pooled event proportions were calculated by biologic class using random-effects meta-analysis with 95% confidence intervals.
Results:
A total of 127 studies including 67,344 treated patients were analyzed. Serious CV outcomes were rare across all biologic classes. Pooled event proportions ranged from 0.0000 to 0.0065, and no class showed a consistent signal of increased event frequency.
Conclusion:
Serious CV events were uncommon during biologic therapy in psoriasis. These findings support the favorable CV safety profile of currently used biologic classes and may aid patient counselling.
Funding:
This study was supported by the 2025-2.1.1-EKÖP-2025-00014 University Research Scholarship Programme of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund, and the Semmelweis 250+ Grant for Excellence.


E-mail address: mv.kolonics@gmail.com
University: Semmelweis University
Supervisors: Prof. Dr. Péter Holló, Dr. András Bánvölgyi
Preferred presentation format: Oral presentation

University

Semmelweis University

Supervisor

Prof. Dr. Péter Holló, Dr. András Bánvölgyi

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem hagyta jóvá

Előadó

7995

Start

15:00

End

15:10