PhD Scientific Days 2026

Poster Session 1.F - Pharmaceutical Sciences and Health Technologies

Development of New Types of Fluorescently Labelled BAPTA Analogues

Előadó neve

Kontra, Bence, MSc

Neptune code

CT0IDE

Előadó munkahelye

Institute of Organic Chemistry

Előadó telefonszáma

06202862500

Előadó e-mail címe

kontra.bence@phd.semmelweis.hu

Az előadás címe

Development of New Types of Fluorescently Labelled BAPTA Analogues

Szerző(k) neve és munkahelye

Bence Kontra^1,2, Zoltán Mucsi^2,3, Petra Dunkel¹

1: Institute of Organic Chemistry, Semmelweis University, Hőgyes Endre utca 7, 1092 Budapest, Hungary
2: Department of Biological Chemistry, Brain Vision Center, Liliom utca 43-45, 1094 Budapest, Hungary
3: Advanced Materials and Intelligent Technologies Higher Education and Industrial Cooperation Centre, University of Miskolc, Miskolc-Egyetemváros, 3515 Miskolc, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session 1.F - Pharmaceutical Sciences and Health Technologies

Language of the presentation

English

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction
Calcium ions play a fundamental role in many physiological processes, such as in muscles, various organs and parts of the nervous system. By monitoring the presence of Ca2+ ions, a visual understanding of cellular processes has become widely available by introducing the active ionophore 1,2-bis(2-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid (BAPTA).
Aims
By attaching different fluorophore units to the BAPTA backbone, we aim to obtain fluorescent sensor molecules whose emission intensity increases upon Ca2+ chelation. By monitoring the emitted signal, the change in the amount of calcium ions in the sample can be followed, and thus, e.g., the activation of neurons can be visualized.
Methods
Synthesis of new BAPTA analogues by organic chemical methods. Analysis of the new sensors by UV/Vis and fluorescent spectroscopy, and by calcium ion titration.
Result
New fluorescent BAPTA derivatives as calcium sensors, which may open the door for using them in human diagnose.
Conclusion
In my presentation, I will show my synthesis and analysis of new fluorescent BAPTA derivatives as calcium sensors, which may open the door for using them in human diagnose.
Funding
This work has been supported by NKFIH, as 2025-1.3.3-NEURO; NKKP Excellence 2025 [153978]; NKKP Starting 2025 [152528]) from the NKFIH, and by the 2025-2.1.1-EKÖP-2025-665 University Research Scholarship Programme (EKÖP)of the Ministry of Culture and Innovation from the National Research, Development and Innovation Fund.

University

Semmelweis University

Supervisor

Dr. Dunkel Petra

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6904

Start

16:36

End

16:39