PhD Scientific Days 2026

Dental Research

SIRT1 in Medication-Related Osteonecrosis of the Jaw

Előadó neve

Dr. Bojtor, Bence

Neptune code

FTJV6V

Előadó munkahelye

Department of Internal Medicine and Oncology, Semmelweis University

Előadó telefonszáma

06204832828

Előadó e-mail címe

bojtor.bence@semmelweis.hu

Az előadás címe

SIRT1 in Medication-Related Osteonecrosis of the Jaw

Szerző(k) neve és munkahelye

Bence Bojtor¹

1: Department of Internal Medicine and Oncology, Semmelweis University

Bemutatás módja

Szóbeli

Szekció

Dental Research

Language of the presentation

Hungarian

Preferred session

Dental Research

Összefoglaló szövege

Introduction
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but severe adverse drug reaction most commonly associated with bisphosphonates and the RANKL-inhibiting antibody used to treat osteoporosis and tumor-related bone loss. The exact pathomechanism of MRONJ remains unclear, but genetic factors may contribute to disease susceptibility.

Aims
To investigate the association between SIRT1 gene polymorphisms and MRONJ, and to evaluate the relationship between SIRT1 serum levels and disease severity.

Method
Genomic DNA was isolated from peripheral blood of MRONJ patients, and four SNPs of the SIRT1 gene were genotyped by Sanger sequencing. Allele frequencies were compared with the European population of the ALFA database. Serum SIRT1 levels were measured by ELISA in MRONJ patients and healthy controls. Group differences were analyzed using non-parametric tests, associations by correlation analyses, and multivariable relationships by principal component analysis (PCA).

Results
The rs932658 genotype distribution in MRONJ patients was 65.1% CC (n=41), 25.4% CA (n=16), and 9.5% AA (n=6), corresponding to a C:A allele ratio of 77.8:22.2, significantly different from the European ALFA population (59.9:40.1; p=4.5×10⁻⁵). PCA revealed additional associations within the studied cohort. A significant negative correlation was observed between MRONJ stage and SIRT1 serum levels in the entire cohort (r=−0.566, p=0.035) and in SIRT1-expressing patients (r=−0.737, p=0.0195).

Conclusion
The rs932658 SNP may help identify patients at increased risk for MRONJ. Decreasing SIRT1 serum levels with increasing disease severity support a potential role of SIRT1 in MRONJ pathogenesis and its possible use in predictive biomarker development.

Funding
This work was supported by the Ministry of Innovation and Technology (2020-4.1.1.-TKP2020-MOLORKIV) and the Hungarian Research Network (SE-ELKH ENDOMOLPAT).

University

Semmelweis University

Supervisor

Dr. Kósa János, Prof. Dr. Lakatos Péter

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem hagyta jóvá

Előadó

8936

Start

09:15

End

09:25