PhD Scientific Days 2026

Poster Session 1.P - Cardiovascular Medicine and Research

Diagnostic and Prognostic Value of Myocardial Flow Reserve Quantification with Single Photon Emission Computed Tomography - a Systematic Review and Meta-Analysis

Előadó neve

Dr. Baksa, Barnabás

Neptune code

CDKK76

Előadó munkahelye

Medical Imaging Centre, Semmelweis University

Előadó telefonszáma

06308771806

Előadó e-mail címe

baksa.barnabas@semmelweis.hu

Az előadás címe

Diagnostic and Prognostic Value of Myocardial Flow Reserve Quantification with Single Photon Emission Computed Tomography - a Systematic Review and Meta-Analysis

Szerző(k) neve és munkahelye

Barnabas Baksa¹, Surendranath Sreeyapureddy Reddy¹, Sára Bundula², Samuel Beke¹, Réka Sebestyén-Dósa¹, István Csulak¹, Kristóf Nagy¹, Lili Száraz¹, Tamás Györke¹, Pál Maurovich-Horvat¹

1: Medical Imaging Centre, Semmelweis University
2: Medical Centre, Hungarian Defence Forces

Bemutatás módja

Poszter

Szekció

Poster Session 1.P - Cardiovascular Medicine and Research

Language of the presentation

English

Preferred session

Cardiovascular Medicine and Research

Összefoglaló szövege

Introduction: Myocardial flow reserve (MFR), assessed through dynamic single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), provides a quantitative measure of coronary physiology, addressing some of the limitations of conventional semi-quantitative SPECT techniques.
Aims: This study aimed to systematically review and meta-analyze the diagnostic accuracy and prognostic value of SPECT-derived MFR compared to invasive coronary angiography (ICA), PET-MPI, and long-term clinical outcomes.
Methods: A comprehensive search of scientific databases identified studies comparing SPECT-derived MFR in patients with suspected or known coronary artery disease (CAD) to ICA, PET-MPI, or ≥12-month follow-up data for major adverse cardiac events (MACE). Meta-analysis was performed using random-effects models for studies comparing SPECT-MFR with PET-MPI, focusing on diagnostic metrics such as sensitivity and specificity.
Results: Thirty-two studies were included (19 comparing SPECT-MFR to ICA, 8 to PET-MPI, 1 to both, and 4 to long-term follow-up). Of these, thirty demonstrated a significant correlation between SPECT-derived MFR and reference standards, with excellent area under the curve (AUC) values (>0.7). In the meta-analysis of six PET-MPI comparator studies (n = 180 participants), the pooled sensitivity for SPECT-MFR was 78.5% (95% CI: 71.7-84.1%) and specificity was 89.3% (95% CI: 70.4-96.7%), yielding a diagnostic odds ratio of 15.7 (95% CI: 6.27-39.27). Prognostic studies confirmed that SPECT-MFR reliably predicted MACE, irrespective of the presence of obstructive coronary disease.
Conclusions: Quantitative MFR derived from dynamic SPECT-MPI correlates strongly with established diagnostic standards and independently predicts adverse cardiovascular events. While PET-MPI remains the reference standard, SPECT-MPI provides a viable, more accessible alternative. Further standardization of protocols and large-scale prospective studies are required to optimize the clinical application of SPECT-derived MFR.
Funding: SE 250+ Excellence PhD Scholarship.

University

Semmelweis University

Supervisor

Prof. Dr. Pál Maurovich-Horvat

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9041

Start

17:06

End

17:09