PhD Scientific Days 2026

Poster Session 2.G - Pharmaceutical Sciences and Health Technologies

Callenges in the Oral Administration of Gastro-Resistant Formulations: The Role of Vehicles and Bottled Waters

Előadó neve

Dr. Demeter, Adrienn Katalin

Neptune code

PGMEP3

Előadó munkahelye

Semmelweis University, Department of Pharmaceutics

Előadó telefonszáma

06307424219

Előadó e-mail címe

demeter.adrienn.katalin@semmelweis.hu

Az előadás címe

Callenges in the Oral Administration of Gastro-Resistant Formulations: The Role of Vehicles and Bottled Waters

Szerző(k) neve és munkahelye

Adrienn Katalin Demeter¹, Dóra Farkas², Márton Király², Ádám Tibor Barna², Krisztina Ludányi², István Antal², Nikolett Kállai-Szabó²

1: Department of Pharmaceutics, Faculty of Pharmacy, Semmelweis University, Hőgyes E. Street 7-9, 1092 Budapest, Hungary
2: Department of Pharmaceutics, Faculty of Pharmacy, Semmelweis University, Hőgyes E. Street 7-9, 1092 Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session 2.G - Pharmaceutical Sciences and Health Technologies

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Background/Objectives: Gastro-resistant multiparticulate systems are designed to protect drugs in acidic environments and to ensure intestinal release. In practice, the method of administration may need to be modified: pellet-containing capsules opened or tablets halved for patients with swallowing difficulties, yet the type of liquid used for administration is often not specified. This study examined the stability of gastro-resistant coated pellets after exposure to various aqueous media prior to ingestion.
Methods: To evaluate administration instructions, 103 Summaries of Product Characteristics of gastro-resistant products were reviewed. Pellets were produced using a bottom-spray fluidized bed process and coated with Eudragit L 30 D-55. Dissolution testing in pH 1.2 medium was performed after pre-soaking the pellets for 5, 15, and 30 min in beverages with various pH and conductivity. Drug release was measured by UV-VIS method, and morphological changes were assessed by image analysis. Marketed gastro-resistant products were also examined visually.
Results: SmPC review revealed that the beverage for intake was frequently unspecified. Among the tested beverages differences in pH and conductivity were observed. Alkaline medicinal mineral waters induced increased and time-dependent premature drug release compared to tap and filtered water. Image analysis indicated a reduction in surface area after exposure to alkaline media.
Conclusions: Contact with non-specified aqueous media before swallowing may weaken the protective function of gastro-resistant films. More explicit recommendations on suitable administration manipulation and media may improve therapeutic consistency.
Funding: SE 250+

University

Semmelweis University

Supervisor

Nikolett Kállai-Szabó

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7981

Start

18:12

End

18:15