PhD Scientific Days 2026

Poster Session 1.F - Pharmaceutical Sciences and Health Technologies

Cell-mediated and peptide-based delivery systems: emerging frontiers in targeted therapeutics

Előadó neve

Dr. Erdei, Eszter, PhD

Neptune code

FIDM1F

Előadó munkahelye

Department of Organic Chemistry

Előadó telefonszáma

+36305611658

Előadó e-mail címe

erdei.eszter@semmelweis.hu

Az előadás címe

Cell-mediated and peptide-based delivery systems: emerging frontiers in targeted therapeutics

Szerző(k) neve és munkahelye

Dr. Eszter Erdei, PhD¹, Dr. István Mándity, PhD¹, Dr. Ruth Deme, PhD¹, Dr. Balázs Balogh, PhD¹

1: Department of Organic Chemistry

Bemutatás módja

Poszter

Szekció

Poster Session 1.F - Pharmaceutical Sciences and Health Technologies

Language of the presentation

English

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction:
Efficient and selective delivery of therapeutic agents remains a central challenge in modern medicine, particularly in the context of biological barriers such as the blood–brain barrier and the tumor microenvironment. Conventional delivery systems often lack specificity, stability, and controlled intracellular release. In this context, cell-mediated and peptide-based delivery platforms have emerged as powerful, bioinspired strategies that integrate molecular recognition, cellular trafficking, and targeted transport.
Aims:
This review aims to provide a comprehensive overview of recent advances in cell-mediated and peptide-assisted delivery systems, highlighting their design principles, mechanistic features, and therapeutic potential across diverse biomedical applications.
Methods:
A systematic analysis of recent literature was conducted, focusing on engineered cellular carriers, cell-penetrating peptides, receptor-targeting motifs, and hybrid nanostructures. Particular emphasis was placed on uptake pathways, endosomal escape mechanisms, structure–function relationships, and preclinical in vitro and in vivo performance.
Results:
Recent advances demonstrate improved delivery efficiency and specificity through rational molecular design and bioengineering. Engineered immune and stem cells show enhanced homing and targeted cargo delivery, while advanced peptide systems enable efficient membrane translocation and cytosolic release. Multifunctional nanostructures integrate targeting, imaging, and therapy, improving BBB penetration and tumor accumulation. However, most systems remain in early preclinical stages with limited clinical translation.
Conclusion:
Cell-mediated and peptide-based delivery systems represent a transformative paradigm in targeted therapeutics, offering unprecedented control over spatial and intracellular drug distribution. However, key challenges—including scalability, safety, reproducibility, and regulatory approval—must be addressed to enable clinical implementation. Continued interdisciplinary integration will be critical to fully realize their therapeutic potential.
Funding:
This work was supported by the Hungarian Research Foundation (OTKA ANN 139484), the National Research, Development and Innovation Office (TKP2021-EGA-31), and the European Union under Project RRF-2.3.1-21-2022-00015.

University

University of Debrecen

Supervisor

Dr. István Mándity, PhD

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

6940

Start

16:54

End

16:57