PhD Scientific Days 2026

Poster Session 2.G - Pharmaceutical Sciences and Health Technologies

Pharmacist-Led Pharmaceutical Care and Statin Adherence in Older Adults: A Randomized Controlled Trial

Előadó neve

Dr. Artner, Anna

Neptune code

B8XAAW

Előadó munkahelye

Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet

Előadó telefonszáma

06304764752

Előadó e-mail címe

artner.anna@semmelweis.hu

Az előadás címe

Pharmacist-Led Pharmaceutical Care and Statin Adherence in Older Adults: A Randomized Controlled Trial

Szerző(k) neve és munkahelye

Dr. Artner Anna¹, Dr. Szélvári Ágnes², Dr. Oláh Ilona², Dr. Ballya Irén², Dr. Hankó Balázs³, Dr. Zelkó Romána³, Dr. Torzsa Péter²

1: Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet
2: Semmelweis Egyetem, Családorvosi tanszék
3: Semmelweis Egyetem, Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet

Bemutatás módja

Poszter

Szekció

Poster Session 2.G - Pharmaceutical Sciences and Health Technologies

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction
Statins are central to cardiovascular prevention, but their real-world effectiveness depends on long-term adherence. Pharmacist-led pharmaceutical care has been proposed to improve adherence and optimize therapy; however, its effectiveness in older adults with established statin use remains uncertain, particularly in populations with high baseline adherence.
Aims
To evaluate the effect of a structured, pharmacist-led pharmaceutical care programme on LDL-C reduction and dispensing-based statin adherence in community-dwelling older adults, and to explore sex-specific differences in outcomes.
Methods
This prospective, parallel-group randomized controlled trial included 100 patients aged ≥65 years receiving long-term statin therapy. Participants were randomized 1:1 to intervention (pharmacist-led consultations every 3 months) or usual care. The primary outcome was change in LDL-C at 6 months. Secondary outcomes included dispensing-based adherence assessed by proportion of days covered (PDC ≥0.80). Analyses were performed per-protocol (INT n=29; CTRL n=33).
Results
No significant between-group difference was observed in LDL-C change (adjusted difference −0.129 mmol/L; p=0.385). Adherence was uniformly high in both groups (PDC ≥0.80: 84–87%), with median six-month dispensing of 6 boxes in both arms. Perfect adherence was observed in ~75% of patients, indicating a ceiling effect. No significant differences in adherence or lipid outcomes were detected. Exploratory analyses suggested sex-specific patterns, including higher low adherence among women in the control group, but these findings were not statistically robust.
Conclusion
In this preliminary 6-month analysis, pharmacist-led pharmaceutical care did not improve statin adherence or LDL-C compared with usual care in older adults with high baseline adherence. The results are likely explained by ceiling effects and limited statistical power. Future studies should target patients with lower baseline adherence, incorporate sex-stratified designs, and include longer follow-up and broader outcome measures.
Funding
No external funding was received for this study.

University

Semmelweis University

Supervisor

Dr. Zelkó Romána, Dr. Hankó Balázs

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8105

Start

18:36

End

18:39