PhD Scientific Days 2026

Poster Session 1.S - Conservative Medicine

Tidal Expiratory Flow Limitation in Lung Transplantation: Insights From Intra-Breath Oscillometry

Előadó neve

Mr. Sipos, Botond

Neptune code

WYXBS5

Előadó munkahelye

Department of Anaesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary

Előadó telefonszáma

+36304873554

Előadó e-mail címe

sipos.botond@stud.semmelweis.hu

Az előadás címe

Tidal Expiratory Flow Limitation in Lung Transplantation: Insights From Intra-Breath Oscillometry

Szerző(k) neve és munkahelye

Botond Sipos¹

1: Department of Anaesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session 1.S - Conservative Medicine

Language of the presentation

Hungarian

Preferred session

Conservative Medicine

Összefoglaló szövege

Introduction: Chronic lung allograft dysfunction (CLAD) is the leading cause of latemortality after lung transplantation (LTx) and is primarily driven by small airway pathology, which may remain undetected by conventional spirometry.

Aims: This study aimed to investigate tidal expiratory flow limitation (tEFL) during spontaneous breathing in lung transplant (LTx) recipients using intra-breath (IB) oscillometry, and to assess its association with CLAD.

Methods: Adult bilateral LTx recipients undergoing routine follow-up at the Toronto General Pulmonary Function Laboratory were assessed using IB oscillometry at 10 Hz (tremoflo®) between November 2018 and December 2024 (median follow-up 18.2 months). A total of 202 CLAD patients were time-matched to 489 CLAD-free controls. tEFL was identified using custom-built software based on characteristic alterations in reactance (X) as a function of flow (V′) and volume (V), quantified by loop-derived indices (AXV′ and AXV). Thresholds distinguished peripheral airway-related tEFL (AXV′ < −1.5 cmH₂O; AXV > 1.0 cmH₂O·s) from upper airway-related patterns (AXV′ > −1.0 cmH₂O; AXV > 1.0 cmH₂O·s). Group comparisons used chi-square, Wilcoxon, Kruskal–Wallis, or t-tests as appropriate.

Results: Most IB oscillometric indices differed significantly between CLAD and CLAD-free patients. Peripheral airway-related tEFL was more frequent in CLAD (18.3%) than in controls (7.8%, p < 0.001). No significant difference was observed for upper airway-related tEFL (CLAD 4.0% vs CLAD-free 7.2%, p = 0.159).

Conclusion: IB oscillometry differentiates CLAD from stable graft function. Peripheral airway-related tEFL may reflect small airway pathology consistent with bronchiolitis obliterans syndrome. Its presence in CLAD-free patients suggests potential for early detection of functional changes preceding spirometric decline.

Funding: This work was supported by the Hungarian Scientific Research Fund (128701).

University

Semmelweis University

Supervisor

Prof. Dr. Zoltán Hantos

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

before finishing undergraduate studies (TDK, MD-PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9827

Start

16:42

End

16:45