PhD Scientific Days 2026

Health Sciences 1.

Beyond Survival: Long-Term Exercise Capacity After Pulmonary Embolism Across Treatment Strategies

Előadó neve

Dr. Stubnya, János Domonkos

Neptune code

Z2T3YH

Előadó munkahelye

Semmelweis University, Department of Intensive Therapy and Semmelweis University, Pediatric Center, Division of Neonatology

Előadó telefonszáma

+36205638010

Előadó e-mail címe

stubnyajanos2000@gmail.com

Az előadás címe

Beyond Survival: Long-Term Exercise Capacity After Pulmonary Embolism Across Treatment Strategies

Szerző(k) neve és munkahelye

János Domonkos Stubnya MD¹, Hanna Dóra Szász MD², Anna Párkányi MD³, Máté Bercz MD³, János Fazakas MD³, András Kállai MD³

1: Semmelweis University, Department of Intensive Therapy and Semmelweis University, Pediatric Center, Division of Neonatology
2: St. John’s Central Hospital of North Buda, Department of Central Anesthesiology and Intensive Therapy
3: Semmelweis University, Department of Intensive Therapy

Bemutatás módja

Szóbeli

Szekció

Health Sciences 1.

Language of the presentation

Hungarian

Preferred session

Health Sciences

Összefoglaló szövege

Introduction: Pulmonary embolism (PE) is a serious condition associated with high mortality and morbidity. A proportion of patients -up to 16% (95% CI 12.8–20.8%; Valerio et al., 2022)- may develop post-PE impairment. Therefore, assessing long-term changes in exercise capacity is crucial for evaluating the effectiveness of different therapeutic strategies and their impact on patient recovery.
Aims: The aim of the study was to analyse long-term outcomes after PE, focusing on exercise capacity, and to compare these parameters across different therapeutic approaches.
Methods: Patients were enrolled in a prospective, randomised interventional trial conducted at the Semmelweis University Department of Intensive Care Medicine (“Safe Implementation of Thrombolysis in PE Using ClotPro Viscoelastic Tests”; ethical approval no. 65187-5/2021/EÜIG). Follow-up at 1, 3, and 12 months, included a 6-minute walk test (6MWT), expressed as a percentage of the predicted values and reported as medians. Patients were divided into three groups: ClotPro-guided thrombolysis (TCP), standard 100 mg rt-PA thrombolysis (TnCP), and no thrombolysis (NT). Statistical analysis waw performed using GraphPad Prism with a mixed-effects model (REML) and Geisser-Greenhouse correction.
Results: A total of 23 patients were analysed, contributing 60 follow-up measurements. Median 6MWT (% of predicted) improved in all groups: TCP: 68.75% → 83.43% → 94.09% (Δ25.33%); TnCP: 64.84% → 74.71% → 79.18% (Δ14.33%); NT: 68.74% → 76.54% → 82.82% (Δ14.09%). A significant main effect of time was observed (F(0.79, 10.62) = 12.76, p = 0.0065), indicating a significant longitudinal improvement, with no significant effect of treatment group or time × treatment interaction was observed.
Conclusion: Exercise capacity improved significantly over time after pulmonary embolism, with no differences between treatment groups. These findings suggest that recovery in functional capacity is primarily time-dependent within the studied cohorts. The absence of group differences may be related to the limited sample size and resulting reduced statistical power, as well as missing follow-up data.
Funding: Supported by the 2025-2.1.1-EKÖP-20025-00014 University Scholarship Programme of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund.

University

Semmelweis University

Supervisor

András Kállai MD

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem hagyta jóvá

Előadó

8126

Start

14:30

End

14:40