PhD Scientific Days 2026

Poster Session 1.I - Theoretical and Translational Medicine

Fabrication, Degradation Dynamics and Mechanical Integrity of Advanced Composite Electrospun Meshes

Előadó neve

Dr. Manikion, Kenigen

Neptune code

L3ZZ27

Előadó munkahelye

Semmelweis University

Előadó telefonszáma

+367039484840

Előadó e-mail címe

kenigen.manikion33@gmail.com

Az előadás címe

Fabrication, Degradation Dynamics and Mechanical Integrity of Advanced Composite Electrospun Meshes

Szerző(k) neve és munkahelye

Kenigen Manikion Dr.¹

1: Semmelweis University

Bemutatás módja

Poszter

Szekció

Poster Session 1.I - Theoretical and Translational Medicine

Language of the presentation

English

Preferred session

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction:
Tissue integration within a biological host is a critical yet challenging aspect of regenerative medicine. When cell adhesion, infiltration, and migration in an implant are insufficient, the immune system may respond by forming a fibrous capsule, isolating the implant and limiting its function. To overcome this issue, researchers have focused on blend and composite materials. Polycaprolactone (PCL) and poly(lactic acid) (PLA) are widely used polymers in biomedical applications due to their biocompatibility, chemical stability, and affordability. However, they present limitations such as hydrophobicity, weak cell adhesion, and slow degradation. In contrast, polysuccinimide (PSI) is a versatile biopolymer known for excellent cell adhesion, strong biocompatibility, and rapid degradation. Combining these polymers offers strong potential for designing advanced materials that enhance tissue integration.
Objectives:
The objective was to fabricate electrospun meshes using different combinations of the biopolymers PCL/PSI and PLA/PSI.
Materials and Methods:
To achieve this, blend-electrospinning was used to produce polysuccinimide/polylactic acid (PSI/PLA) and polysuccinimide/polycaprolactone (PSI/PCL) meshes. The resulting meshes underwent chemical, physical, and mechanical characterization.
Results:
Scanning electron microscopy confirmed the absence of structural defects. ATR-FTIR analysis verified the presence of both polymers in the meshes. PSI/PLA fibers had an average diameter of 650 nm, while PSI/PCL fibers averaged 600 nm. The PSI/PCL mesh showed a specific loading capacity of 0.250 Nm²/g, whereas PSI/PLA reached 0.061 Nm²/g. Both meshes exhibited weight loss over time, accompanied by a gradual decline in mechanical performance, as tensile strength decreased during degradation.
Conclusion:
The blend-electrospun PSI/PLA and PSI/PCL meshes demonstrated promising potential for tissue integration. Both maintained structural integrity while degrading, with a progressive reduction in tensile strength. PSI/PCL showed higher mechanical strength than PSI/PLA. These materials provide a solid basis for future regenerative medicine applications.

University

Semmelweis University

Supervisor

Dr. Voniatis Constantinos

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8104

Start

17:18

End

17:21