PhD Scientific Days 2026

Poster Session 3.W - Pharmaceutical Sciences and Health Technologies

Pharmaceutical applications of melt-spinning technology

Előadó neve

Dr. Kecskés, Bálint Attila

Neptune code

shxpd4

Előadó munkahelye

Semmelweis University, Department of Pharmaceutics

Előadó telefonszáma

06308364523

Előadó e-mail címe

kecskes.balint@stud.semmelweis.hu

Az előadás címe

Pharmaceutical applications of melt-spinning technology

Szerző(k) neve és munkahelye

dr. Kecskés Bálint Attila¹, dr. Filipszki Gábor¹, Dr. Kállai-Szabó Nikolett¹, Prof. Dr. István Antal¹

1: Semmelweis University, Department of Pharmaceutics

Bemutatás módja

Poszter

Szekció

Poster Session 3.W - Pharmaceutical Sciences and Health Technologies

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction: Melt-spinning is a widely used technology applied in various industries, including construction, textiles, and food, thereby opening the possibility of its application in the pharmaceutical field. Microfibrous systems provide several benefits in pharmaceutical technology, such as enabling instantaneous dissolution due to their high specific surface area and amorphous structure, making them suitable for the development of innovative new drug forms.

Aim: The aim of the present study was to produce isomalt-based microfibers containing ibuprofen sodium with enhanced resistance to environmental humidity. An additional objective was to monitor potential physico-chemical changes occurring during fiber formation and subsequent treatment through both microstructural and macrostructural analyses.

Materials and Methods: The preparation of the fibers required the formulation of a homogeneous premix to ensure uniform distribution of all components. Following melt-spinning, the fibers were exposed to ethanol vapor treatment in order to improve their stability and resistance to environmental humidity. The macrostructure of the fibers was evaluated using a digital microscope, allowing observation of their morphology and overall structure. Microstructural properties were investigated using differential scanning calorimetry and X-ray powder diffraction to assess thermal behavior and solid-state characteristics. In addition, in vitro solubility testing was performed on fibers containing ibuprofen sodium to evaluate their dissolution behavior.

Results: The study resulted in the successful production of drug-containing microfibers that exhibited a high degree of resistance to ambient humidity. The fibers maintained their structural integrity and stability under varying environmental conditions, confirming the effectiveness of the applied preparation and stabilization methods.

Conclusion: Drug-containing microfibers were successfully developed with favorable structural and stability characteristics. These systems may facilitate further pharmaceutical processing and provide a basis for the development of innovative dosage forms with improved performance.

Funding: This work was supported by SE 250+ Excellence PhD Scholarship Application.

University

Semmelweis University

Supervisor

Dr. Kállai-Szabó Nikolett

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9802

Start

13:54

End

13:57