PhD Scientific Days 2026

Theoretical and Translational Medicine 3.

Multifunctional Electrospun Polysuccinimide Scaffolds with ZnO and Magnetic Nanoparticles

Előadó neve

Halmóczki, Sarolta

Neptune code

DUZ8PP

Előadó munkahelye

Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University

Előadó telefonszáma

06209931800

Előadó e-mail címe

halmoczki.sarolta@phd.semmelweis.hu

Az előadás címe

Multifunctional Electrospun Polysuccinimide Scaffolds with ZnO and Magnetic Nanoparticles

Szerző(k) neve és munkahelye

Sarolta Halmóczki¹, Vivien Rizmajer¹, Edina Bugyik², Angéla Jedlovszky-Hajdú¹

1: Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University
2: Department of Genetics Cell- and Immunobiology, Semmelweis University

Bemutatás módja

Szóbeli

Szekció

Theoretical and Translational Medicine 3.

Language of the presentation

English

Preferred session

Theoretical and Translational Medicine

Összefoglaló szövege

Introduction: Chronic infected wounds represent a major clinical challenge, associated with prolonged healing and high healthcare burden, particularly due to the increasing prevalence of multidrug-resistant (MDR) bacteria, which limit the effectiveness of conventional antibiotics. Advanced wound dressings that combine antibacterial activity, biodegradability, and diagnostic functionality are urgently needed. Zinc oxide nanoparticles (ZnONPs) exhibit broad-spectrum antibacterial effects, while magnetic nanoparticles (MNPs) enable imaging. Poly(succinimide) (PSI) is a biodegradable polymer that reportedly degrades within five days under physiological conditions.

Aims: To develop electrospun PSI scaffolds incorporating ZnO NPs and MNPs, and to compare their antibacterial, mechanical, and imaging properties. Coaxial electrospinning was applied to enhance performance and multifunctionality.

Methods: MNPs were synthesized by co-precipitation method, ZnONPs in an organic medium. Nanocomposite scaffolds were produced via single-needle and coaxial electrospinning. Characterization included DLS, UV–Vis, TEM, SEM, and EDX. Mechanical properties were assessed by tensile testing, while MRI contrast and antibacterial activity (Kirby–Bauer) were evaluated.

Results: ZnONP-containing scaffolds demonstrated clear antibacterial activity. MNP incorporation provided MRI contrast enhancement, indicating suitability as a contrast agent. Single-needle ZnO systems showed limited mechanical strength, whereas coaxial fibers improved mechanical properties and enabled multifunctional designs. Coaxial MNP–ZnO samples exhibited distinct mechanical behavior compared to blended systems.

Conclusion: PSI-based electrospun scaffolds incorporating ZnONPs and MNPs show potential as multifunctional wound dressings with antibacterial and imaging capabilities. Coaxial architectures enhance mechanical performance and support theranostic applications. Future work will address cytotoxicity, dissolution behavior, and hyperthermia potential.

Funding: This research was supported by NKFIH FK 137749; TKP2021-EGA-23; and the Pannonia Scholarship Programme.

University

Semmelweis University

Supervisor

Dr Jedlovszky-Hajdú Angéla

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem hagyta jóvá

Előadó

8019

Start

11:45

End

11:55