PhD Scientific Days 2026

Poster Session 2.E - Pathological and Oncological Sciences

Obesity and Survival in Endometrial Cancer

Előadó neve

Karadocsev, Éva, MSc

Neptune code

A61GXZ

Előadó munkahelye

Semmelweis University, Department of Bioinformatics

Előadó telefonszáma

+36300164582

Előadó e-mail címe

evakaradocsev@gmail.com

Az előadás címe

Obesity and Survival in Endometrial Cancer

Szerző(k) neve és munkahelye

Éva Karadocsev MSc¹, Prof. Dr. Balázs Győrffy¹

1: Semmelweis University, Department of Bioinformatics

Bemutatás módja

Poszter

Szekció

Poster Session 2.E - Pathological and Oncological Sciences

Language of the presentation

English

Preferred session

Pathological and Oncological Sciences

Összefoglaló szövege

Introduction:
Obesity is commonly linked to the development of endometrial cancer, but its prognostic relevance after diagnosis is still debated. This meta-analysis aimed to evaluate whether higher body mass index (BMI) influences overall survival among patients diagnosed with endometrial cancer.

Aims:
This meta-analysis was conducted to determine whether elevated body mass index (BMI) is associated with increased overall mortality in individuals diagnosed with endometrial cancer.

Methods:
We analysed 61 BMI-related comparisons across 26 independent studies, all of which reported hazard ratios (HRs) for mortality stratified by BMI category. A random-effects model using inverse variance weighting was applied to estimate the overall effect. Heterogeneity between studies was measured using the I² statistic. To assess potential reporting bias, funnel plot visualization and Egger’s linear regression test were performed.

Results:
The combined HR was 1.29 (95% CI: 1.19–1.4), indicating that higher BMI was associated with an increased risk of death (p < 0.05). Considerable (I² = 82%, p < 0.01) heterogeneity was observed across studies, suggesting meaningful variability in effect sizes. The included studies differed substantially in their sampling methods, population characteristics, follow-up durations, and adjustments for confounding factors, which may obscure the true impact of obesity on survival. Moreover, the funnel plot indicated potential publication bias, and Egger’s test (intercept = 1.09, 95% CI: 0.48–1.7; p = 0.001) confirmed asymmetry, suggesting that smaller studies with null or negative findings might be underrepresented. Together, these factors highlight that methodological differences and selective reporting could mask or distort the actual effect of high BMI on patient outcomes.

Conclusion:
Excess body weight is associated with poorer survival in individuals with endometrial cancer. These findings highlight a statistically significant association based on a random-effects model using inverse variance weighting. Future studies should focus on disentangling the role of adiposity-related biological mechanisms and the contribution of body composition.

Funding:
This research was supported by the University Research Scholarship Programme (EKÖP), the Ministry of Culture and Innovation, and the National Research, Development and Innovation Fund.

University

Semmelweis University

Supervisor

Prof. Dr. Balázs Győrffy

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9140

Start

18:12

End

18:15