PhD Scientific Days 2026

Poster Session 2.B - Molecular Medicine

Identifying a Possible New Therapeutic Option for Atherosclerosis

Előadó neve

Sági, Stella, MSc

Neptune code

G6NO54

Előadó munkahelye

Semmelweis University, Department of Physiology

Előadó telefonszáma

+36307009163

Előadó e-mail címe

sagi.stella.marta@semmelweis.hu

Az előadás címe

Identifying a Possible New Therapeutic Option for Atherosclerosis

Szerző(k) neve és munkahelye

Stella Sági¹, Anna Horváth², Zoltán Jakus¹

1: Semmelweis University, Department of Physiology
2: AnnaHorist Ltd.

Bemutatás módja

Poszter

Szekció

Poster Session 2.B - Molecular Medicine

Language of the presentation

Hungarian

Preferred session

Molecular Medicine

Összefoglaló szövege

Introduction: Cardiovascular diseases, including atherosclerosis, remain a leading cause of morbidity and mortality worldwide, highlighting the urgent need for effective therapeutic strategies. Atherosclerosis is characterized by the accumulation of lipid-rich plaques within the vascular wall, resulting in vessel wall thickening and luminal narrowing. Despite advances in current treatments, disease progression is often insufficiently controlled. Macrophages play a central role in the atherosclerotic process and therefore represent a promising target for therapeutic intervention.
Aims: Our objective is to advance the understanding of atherosclerosis pathogenesis and to explore novel therapeutic strategies. To this end, we conduct a comprehensive preclinical evaluation of ACHA, an experimental compound developed by AnnaHorist Ltd.
Methods: An immortalized macrophage cell line was used to assess cellular uptake of ACHA. Atherosclerosis was induced in transgenic LDLR-/- mice via high-fat diet, followed by intravenous administration of the compound. Blood samples were collected to determine cholesterol, LDL, and HDL levels. Lipid accumulation in the aortic arch was evaluated by stereomicroscopy and Oil Red O staining.
Results: Our findings demonstrate rapid uptake of ACHA by macrophages, detectable as early as 5 minutes. A sex-dependent difference in disease progression was observed, with increased lipid deposition in female mice compared to males. Both stereomicroscopy and Oil Red O staining showed a reduction in aortic plaque in ACHA-treated mice compared to controls, consistent across both sexes, supporting the therapeutic potential of ACHA.
Conclusion: These findings suggest that ACHA may attenuate atherosclerosis progression; however, further studies are required to optimize dosing and administration strategies and to elucidate sex-specific differences in disease progression. Overall, our results support the potential of targeted molecular interventions as emerging therapeutic approaches in cardiovascular disease.
Funding: Project No. 2023-2.1.2-Kdp-2023-00016

University

Semmelweis University

Supervisor

Zoltán Jakus

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9756

Start

18:42

End

18:45