PhD Scientific Days 2026

Poster Session 1.F - Pharmaceutical Sciences and Health Technologies

Modified PVA-Based Nanofibrous Systems as Dual-Functional Wound Dressings for Controlled Drug Delivery in Burn Injury Management

Előadó neve

Dr. Nochta-Kazsoki, Adrienn

Neptune code

R5CDJV

Előadó munkahelye

University Pharmacy Department of Pharmacy Administration, Semmelweis Univeristy, Budapest, Hungary

Előadó telefonszáma

06302060093

Előadó e-mail címe

kazsoki.adrienn@semmelweis.hu

Az előadás címe

Modified PVA-Based Nanofibrous Systems as Dual-Functional Wound Dressings for Controlled Drug Delivery in Burn Injury Management

Szerző(k) neve és munkahelye

Dr. Adrienn Nochta-Kazsoki¹, Dorka Simon¹, Romána Zelkó¹

1: University Pharmacy Department of Pharmacy Administration, Semmelweis Univeristy, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session 1.F - Pharmaceutical Sciences and Health Technologies

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction: Burn wound management remains a major clinical challenge, particularly when rapid regeneration and scar-free healing are desired. Prolonged inflammation and infection impair healing and increase the risk of pathological scar formation, including hypertrophic scarring and keloid formation.
Aims: This study aimed to develop a nanofiber-based wound dressing system combining arginine and chlorhexidine to support different phases of burn wound healing.
Methods: Nanofibrous mats were produced by electrospinning using poly(vinyl alcohol) (PVA)-based systems, including TEOS-modified PVA and PVA–chitosan blends. Precursor composition and process parameters were optimized. Morphology was characterized by scanning electron microscopy, while physicochemical properties were analyzed using FTIR and X-ray diffraction. In vitro drug release profiles were evaluated.
Results: The developed nanofibrous systems exhibited uniform, bead-free morphology with appropriate fiber diameter distribution. FTIR analysis confirmed the successful incorporation of the active agents and suggested intermolecular interactions within the modified PVA-based matrices. X-ray diffraction patterns indicated the formation of an amorphous solid dispersion. In vitro release studies demonstrated controlled release behavior, supporting the suitability of the system for sustained drug delivery.
Conclusion: Modified PVA-based nanofibrous systems incorporating arginine and chlorhexidine represent a promising approach for supporting burn wound healing by providing controlled drug delivery and a favorable wound environment.
Funding: This project is supported by the 202-2.1.1.-EKÖP-2025-00014 University Research Scholarship Programme of the Ministry for Culture and Innovation, funded by the National Research, Development and Innovation Fund.

University

Semmelweis University

Supervisor

Romána Zelkó

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

8016

Start

17:12

End

17:15