PhD Scientific Days 2026

Pharmaceutical Sciences and Health Technologies 4.

Cyclodextrin inclusion complexes of Boswellia serrata extract: comparative in vitro evaluation of dissolution enhancement and intestinal permeability

Előadó neve

Stifter-Mursits, Marcell, MSc

Neptune code

OGN891

Előadó munkahelye

Department of Pharmaceutical Chemistry - Semmelweis University

Előadó telefonszáma

+36303223023

Előadó e-mail címe

stifter.mursits.marcell@semmelweis.hu

Az előadás címe

Cyclodextrin inclusion complexes of Boswellia serrata extract: comparative in vitro evaluation of dissolution enhancement and intestinal permeability

Szerző(k) neve és munkahelye

Marcell Stifter-Mursits¹, Réka E. Angi¹, Vivien Bárdos¹, György T. Balogh¹, Péter Püski²

1: Department of Pharmaceutical Chemistry - Semmelweis University
2: Institute of Pharmacognosy - University of Szeged

Bemutatás módja

Szóbeli

Szekció

Pharmaceutical Sciences and Health Technologies 4.

Language of the presentation

Hungarian

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction

Cyclodextrins (CDs) are cyclic oligosaccharides capable of forming inclusion complexes with lipophilic compounds, improving their solubility, permeability and pharmacokinetical performance. Boswellic acids (BAs), derived from Boswellia serrata resin, exhibit anti-inflammatory and other pharmacological activities, but are limited by extremely low aqueous solubility (less than 10 µg/mL) and poor pharmacokinetics.

Aims

Our study focused on the systematic evaluation of CD–BA interactions using complementary in vitro and ex vivo models to identify formulations capable of overcoming solubility- and permeability-related limitations.

Methods

Multiple CDs differing in cavity size and charge were screened. Selected systems were characterized by PXRD, FT-IR, and DSC. Pharmacokinetic performance was assessed using dissolution in biorelevant media, paralell artificial membrane permeation assay (PAMPA), and ex vivo permeation across porcine small intestine.

Results

The feasibility results indicated that CDs with larger cavity size and neutral charge show better interaction with BAs. The solid-state analyses confirmed the formation of inclusion complexes with the native γ-CD. The dissolution of BAs was improved over 10-fold in fasted-state media and enabled complete drug release in fed-state. The effective permeability of BAs in fasted-state was significantly higher in our PAMPA model with both γ-CD and HP-γ-CD. Ex vivo studies established γ-CD as the superior excipient with 15-fold increase in the concentration of BAs on the acceptor side.

Conclusions

Cyclodextrin selection was identified as the critical determinant of formulation performance for boswellic acids. Among the systems investigated, γ-CD consistently provided the most favorable outcomes across solid-state characterization, dissolution, and permeability studies. These findings establish native γ-CD as the optimal excipient for further development of Boswellia formulations.

Funding

The Boswellia Serrata Roxb. extracts were received from the Department of Pharmacognosy, University of Szeged, Hungary. The cyclodextrins used in the study were kind gifts of CycloLab Ltd., Budapest, Hungary.


stifter.mursits.marcell@semmelweis.hu – oral presentation
Semmelweis University – Department of Pharmaceutical Chemistry
Prof. Balogh György Tibor

University

Semmelweis University

Supervisor

György Tibor Balogh

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem hagyta jóvá

Előadó

9076

Start

17:15

End

17:25