PhD Scientific Days 2026

Poster Session 1.O - Dental Research

Effects of antihypertensive medications on salivary secretion and oral health

Előadó neve

Dr. Kovács, Alexandra

Neptune code

OP1311

Előadó munkahelye

Department of Restorative Dentistry and Endodontics

Előadó telefonszáma

06305297071

Előadó e-mail címe

kovacs.alexandra@semmelweis.hu

Az előadás címe

Effects of antihypertensive medications on salivary secretion and oral health

Szerző(k) neve és munkahelye

Dr.Alexandra Kovács¹, Dr.Enikő Szabó¹, Dr.Zsolt Lohinai¹, Dr.Krisztina Márton²

1: Department of Restorative Dentistry and Endodontics
2: Department of Preclinical Dentistry

Bemutatás módja

Poszter

Szekció

Poster Session 1.O - Dental Research

Language of the presentation

English

Preferred session

Dental Research

Összefoglaló szövege

Introduction
Antihypertensive medications are widely used and are known to affect salivary function, with several drug classes associated with xerogenic side effects. However, comparative data on their effects on objective salivary parameters and clinical oral health measures are limited.
Aims
This study aimed to compare objective salivary and oral health parameters among patients receiving different antihypertensive therapies (CVD) who were awaiting major cardiovascular surgery and healthy controls.
Method
A cross-sectional study was conducted including a control group and patients receiving antihypertensive medication needing cardiovascular surgery for aorta aneurysm and carotid stenosis. Patients were categorized into five groups: beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), calcium channel blockers, and diuretics. Unstimulated whole saliva (UWS) and minor salivary gland (MSG) secretion were measured. Oral health parameters included Silness-Löe Plaque Index (SLPI), bleeding on probing (BOP), probing pocket depth (PPD), and DMFT index. Group differences were analysed using Kruskal–Wallis test with post hoc Mann–Whitney U test where appropriate.
Results
Significant differences were observed in UWS (p<0.001) between the control and CVD patients. Post hoc analysis with Bonferroni correction showed higher UWS in ARB (0.69 [0.36–1.08] ml/min) and diuretic groups (1.08 [0.52–1.11] ml/min) compared to controls (0.13 [0.08–0.34] ml/min), while calcium channel blockers showed borderline significance (0.44 [0.24–1.08] ml/min). No significant differences were found for beta-blockers or ACE inhibitors. No differences were observed in MSG secretion, DMFT, BOP, or PPD; these variables were not further analysed.
Conclusion
Antihypertensive drug classes may affect salivary function, with higher UWS observed in ARB and diuretic groups. No differences were found in minor salivary gland secretion or clinical oral parameters. These findings differ from commonly reported xerogenic effects and suggest a more complex, drug class–specific influence on salivary flow. However, as these are preliminary results based on a small sample, further studies are needed.
Funding
No funding.

University

Semmelweis University

Supervisor

Dr.Krisztina Márton

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9738

Start

16:54

End

16:57