PhD Scientific Days 2026

Health Sciences 3.

Effect of telemedicine-delivered lifestyle interventions in older adults during the COVID-19 pandemic: a nationwide two-arm randomized trial (PROACTIVE-19)

Előadó neve

Dr. Váncsa, Szilárd, MSc, PhD

Neptune code

KXJRHR

Előadó munkahelye

Institute of Pancreatic Diseases and Centre for Translational Medicine, Semmelweis University

Előadó telefonszáma

06300164408

Előadó e-mail címe

vancsaszilard@gmail.com

Az előadás címe

Effect of telemedicine-delivered lifestyle interventions in older adults during the COVID-19 pandemic: a nationwide two-arm randomized trial (PROACTIVE-19)

Szerző(k) neve és munkahelye

Szilárd Váncsa¹, Anett Nagy-Szakolczai², Roland Molontay², Emőke Miklós³, Andrea Szentesi³, Klementina Ocskay⁴, Péter Jenő Hegyi¹, Judit Hegyi⁵, Anna Hegyi⁵, Eszter Hegyi⁵, Dóra Czapári⁵, Zsolt Molnár⁶, Bálint Erőss¹, Péter Hegyi¹

1: Centre for Translational Medicine and Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary
2: Institute of Biostatistics and Network Science, Semmelweis University, Budapest, Hungary
3: Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
4: Heim Pál National Pediatric Institute, Budapest, Hungary
5: Centre for Translational Medicine, Semmelweis University, Budapest, Hungary
6: Centre for Translational Medicine and Department of Anesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary

Bemutatás módja

Szóbeli

Szekció

Health Sciences 3.

Language of the presentation

English

Preferred session

Health Sciences

Összefoglaló szövege

Introduction:
Older adults are at increased risk of severe COVID-19 outcomes, yet randomized evidence on structured lifestyle interventions in this context remains limited.
Aims:
We aimed to determine whether a personalized lifestyle intervention could improve health-related behaviours and reduce adverse outcomes among adults aged ≥60 years.
Methods:
PROACTIVE-19 was a nationwide, open-label, randomized trial conducted in Hungary. Participants aged ≥60 years were randomly assigned (1:1) to general (Group A) or personalized (Group B) lifestyle counselling delivered via telephone, targeting mental health, smoking, physical activity, diet, and alcohol consumption. The primary planned endpoint was a composite of COVID-19 severity outcomes; however, due to infection rates, all-cause mortality was assessed. Longitudinal lifestyle changes were evaluated using linear mixed-effects models with bootstrap confidence intervals (95% CI) in a modified intention-to-treat population.
Results:
Between March 26, 2020, and study closure, 441 participants were analyzed (214 Group A; 227 Group B). All-cause mortality was lower in Group B (HR=0·66, CI 0·28–1·53), but the difference was not statistically significant. Significant overall time effects were observed for fruit and vegetable consumption (β=0·052, CI 0·026–0·074), smoking reduction among current smokers (β=−0·372, CI −0·528 to −0·222), and psychological variables. A significantly greater reduction in estimated alcohol consumption was observed in Group B among baseline drinkers compared with Group A (β=−1·357, CI −2·425 to −0·187), particularly in women. However, BMI among participants with obesity increased in group B (β=0·068, CI 0·013–0·119). Seasonal and pandemic-wave effects significantly influenced physical activity and psychological distress.
Conclusion:
The personalized intervention was not associated with a significant reduction in all-cause mortality. Several lifestyle behaviours improved over time, however, the additional benefit of personalization was limited
Funding:
SV was supported by the EKÖP-2025-434 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund.

University

Semmelweis University

Supervisor

-

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

after finishing doctoral studies with absolutorium (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9123

Start

12:15

End

12:25