PhD Scientific Days 2026

Neurosciences

The effects of Alzheimer's disease on the autonomic nervous system

Előadó neve

Dr. Váraljai, Christopher

Neptune code

H4D4SE

Előadó munkahelye

Department of Neurointervention and Neurosurgery - Semmelweis University

Előadó telefonszáma

+36704253655

Előadó e-mail címe

christophervaraljai@gmail.com

Az előadás címe

The effects of Alzheimer's disease on the autonomic nervous system

Szerző(k) neve és munkahelye

Dr. Christopher Váraljai¹

1: Department of Neurointervention and Neurosurgery - Semmelweis University

Bemutatás módja

Szóbeli

Szekció

Neurosciences

Language of the presentation

Hungarian

Preferred session

Neurosciences

Összefoglaló szövege

Introduction: Alzheimer's disease (AD) is the most common major neurocognitive disorder. Its symptoms include memory impairment, loss of acquired knowledge and learning ability, and deterioration of behaviour and personality. The neuropathology of the disease suggests that protein aggregates also accumulate in the brain structures involved in the integration of autonomic functions. Since these regions are also affected in the early stages of AD, they may potentially aid in the early detection of the disease by causing measurable symptoms. Very few articles have addressed this possibility to date.
Objective: The aim of our study is to determine whether the symptoms resulting from AK's effects on the autonomic nervous system—HRV and sudomotor sympathetic skin response (SSR) abnormalities—can be used for early diagnosis of the disease and for the differential diagnosis of other major neurocognitive disorders.
Method: We examined 89 patients, 11 of whom were diagnosed with mild cognitive impairment (MCI), 12 with AD, 6 with other major neurocognitive disorders (non-AD), and 60 had no such disease (healthy control, HC). We measured the patients' HRV values using a single-lead ECG called WIWE. We mapped the patients' SSR values using a system called Vitalscan Sudocheck. We evaluated the measured data using JASP 0.18.0.0 statistical software.
Results: Based on ANOVA, there was a significant (p=0.024) difference between the groups in terms of HRV values, and based on an independent sample t-test, there was a significant (p<0.05) difference between the HC and non-AD, and MCI and non-AD groups. In terms of SSR values, ANOVA showed a significant (p<.001) difference between the groups, and an independent sample t-test showed a significant (p<0.05) difference between the HC and MCI populations, the HC and non-AD populations, the MCI and AD populations, and the AD and non-AD populations.
Conclusion: HRV abnormalities worsen during the progression of AD and non-AD. SSR values were lower in the MCI and non-AD populations, while they did not change in AD compared to the control group. Therefore, it is conceivable that MCI patients whose SSR values deteriorated will progress to non-AD, while those whose values did not deteriorate will progress to AD.

University

Semmelweis University

Supervisor

Prof. Dr. Anita Kamondi

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9002

Start

15:30

End

15:40