PhD Scientific Days 2026

Poster Session 1.I - Theoretical and Translational Medicine

Pretreating Aged Mouse Hearts with the NAD⁺ Precursor NMN Confers Cardioprotective Benefits

Előadó neve

Fülöp, Ágnes

Neptune code

V0IZY8

Előadó munkahelye

Semmelweis University, Institute of Clinical Pathophysiology

Előadó telefonszáma

+36305808606

Előadó e-mail címe

fulop.agnes@semmelweis.hu

Az előadás címe

Pretreating Aged Mouse Hearts with the NAD⁺ Precursor NMN Confers Cardioprotective Benefits

Szerző(k) neve és munkahelye

Ágnes Fülöp¹, Vanessza Yit Sokpanya², Anna Csiszár³, Zoltán Ungvári⁴, Zoltán Benyó¹, Zsuzsanna Miklós⁵

1: 1 Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary 2 HUN-REN-SU Cerebrovascular and Neurocognitive Diseases Research Group, Budapest, Hungary
2: 1 Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary
3: 3 Vascular Cognitive Impairment, Neurodegeneration and Healthy Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA 4 Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA 5 The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA 6 International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Institute for Translational Medicine, Semmelweis University, Budapest, Hungary
4: 3 Vascular Cognitive Impairment, Neurodegeneration and Healthy Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA 4 Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA 6 International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Institute for Translational Medicine, Semmelweis University, Budapest, Hungary 7 Fodor Center for Prevention and Healthy Aging, Semmelweis University, Budapest, Hungary
5: 1 Institute of Clinical Pathophysiology, Semmelweis University, Budapest, Hungary 8 National Korányi Institute for Pulmonology, Budapest, Hungary

Bemutatás módja

Poszter

Szekció

Poster Session 1.I - Theoretical and Translational Medicine

Language of the presentation

English

Preferred session

Theoretical and Translational Medicine

Összefoglaló szövege

During aging, nicotinamide adenine dinucleotide (NAD+) depletion and impairment of cardiac ischemia tolerance can develop.
Our aim was to explore whether treatment with NAD+ precursor (nicotinamide mononucleotide, NMN) improves heart function and prevents enhanced ischemic damage in old hearts.
After pretreatment of young and old (4 and 26 months old) C57Bl/6N male mice with NMN (500 mg/kg/day ip.) or carrier (PBS) for 2 weeks, echocardiographic examination was performed. Afterwards, hearts were isolated and perfused with constant pressure in a Langendorff system. The hearts were exposed to 23 minutes of global ischemia, followed by a 120-minute reperfusion period. Coronary flow and left ventricular (LV) pressure changes were measured, and LV infarct size was determined.
In elderly hearts, echocardiography showed enlargement of the left ventricle, however ejection fraction was preserved. NMN treatment did not affect the echocardiographic parameters. The ratio of the infarcted area in LV of old mice was significantly higher compared to the young mice. After NMN pretreatment, the myocardial infarction size of the old hearts decreased. The postischemic coronary flow and functional restitution of old hearts were impaired compared to young controls, however NMN treatment restored this impairment.
Pretreatment with NAD+ precursor does not affect the resting heart function, whereas it significantly reduces the consequences of cardiac ischemia in hearts of aged mice; it has a favorable effect both on infarct size and on postischemic functional recovery.
Funding: NRDIO K-125174, K-139230, K151053; ÚNKP-22-4-II-SE-17; RRF-2.1.2.-12-2022-0001; TKP2021-EGA-25; R01AG055395, R01AG068295, R01AG070915, R01NS100782, R01CA255840.

University

Semmelweis University

Supervisor

Prof. Dr. Zoltán Benyó and Dr. Zsuzsanna Miklós

Publication of my abstract

I do not give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies after complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

7514

Start

17:42

End

17:45