PhD Scientific Days 2026

Poster Session 3.W - Pharmaceutical Sciences and Health Technologies

Review on the application of metalloporphyrin catalysts as cytochrome P450 enzyme mimics in biomimetic modeling

Előadó neve

Abdulhussein, Ahmed, PhD

Neptune code

JK6PW3

Előadó munkahelye

Semmelweis University, pharmaceutical chemistry department

Előadó telefonszáma

+36705489227

Előadó e-mail címe

ahmed.abdulhussein@phd.semmelweis.hu

Az előadás címe

Review on the application of metalloporphyrin catalysts as cytochrome P450 enzyme mimics in biomimetic modeling

Szerző(k) neve és munkahelye

Ahmed Abdulhussein¹

1: Semmelweis University, pharmaceutical chemistry department

Bemutatás módja

Poszter

Szekció

Poster Session 3.W - Pharmaceutical Sciences and Health Technologies

Language of the presentation

English

Preferred session

Pharmaceutical Sciences and Health Technologies

Összefoglaló szövege

Introduction: Drug metabolism studies are important in pharmaceutical research for predicting the safety and metabolic fate of drug candidates. Conventional cytochrome P450 (CYP450)-based systems are widely used but are often costly, time-consuming, and limited in stability. Metalloporphyrins (MPs), due to their similarity to CYP450 heme centers, have emerged as promising biomimetic catalysts for oxidative drug metabolism. Advances in immobilization methods, nanostructured supports, and continuous-flow systems have expanded their applications in metabolite synthesis and mechanistic studies.
Aims: To review recent advances (2015–2026) in metalloporphyrin-based biomimetic catalysis for oxidative drug metabolism, compare MPs with conventional CYP450 systems, and evaluate innovations in immobilization and continuous-flow applications.
Methods: A literature review of studies published between 2015 and 2025 was conducted. Metalloporphyrin-catalyzed oxidative drug metabolism studies were analyzed and compared with CYP450-based models regarding selectivity, stability, scalability, and functional group tolerance. Recent developments in immobilized catalysts, nanomaterials, and microreactor technologies were also reviewed.
Results: Metalloporphyrins showed strong potential as biomimetic oxidation catalysts for drug metabolism studies. Compared with enzymatic systems, MPs offer lower cost, improved stability, and easier scalability. Immobilization and nanotechnology improved catalyst efficiency and reusability, while continuous-flow systems enhanced reaction control and metabolite production. However, challenges remain in achieving high regioselectivity.
Conclusion: Metalloporphyrins are valuable complementary tools for oxidative drug metabolism and metabolite synthesis. Advances in catalyst design and flow technologies highlight their growing role in pharmaceutical research and drug discovery.
Funding: This work received no specific funding from public, commercial, or non-profit organizations.

University

Semmelweis University

Supervisor

Balázs Volk and György Tibor Balogh

Publication of my abstract

I give consent to the publication of my abstract on the website of the congress.

phd.section.field

in doctoral studies before complex exam (PhD)

Kind

Szabad

Status

elfogadva

Accepted presentation method

poszter

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

9841

Start

14:12

End

14:15