PhD Scientific Days 2026

Cardiovascular Medicine and Research 1.

Identifying High-Risk Patients for Endovascular Failure with UTE-MRI

Előadó neve

Dr. Csőre, Judit

Előadó e-mail címe

csore.judit@semmelweis.hu

Az előadás címe

Identifying High-Risk Patients for Endovascular Failure with UTE-MRI

Szerző(k) neve és munkahelye

Dr. Csőre Judit¹

1: Semmelweis University, Heart and Vascular Center

Bemutatás módja

Szóbeli

Szekció

Cardiovascular Medicine and Research 1.

Összefoglaló szövege

Introduction: Endovascular treatment failure in chronic limb-threatening ischemia (CLTI) is not fully understood, and patient selection is crucial for optimal results. Ultrashort Echo Time (UTE) MRI is a non-contrast method shown ex vivo to characterize plaque composition.
Aims: This study assessed whether MRI-defined plaque morphology influences procedural difficulty and immediate technical failure (ITF) in peripheral vascular interventions (PVI).
Methods: Patients with CLTI undergoing PVI at a tertiary vascular center were enrolled and underwent 3T UTE-MRI. Lesions were classified as predominantly soft (>50% thrombus, cholesterol/lipid plaque) or hard (calcific/collagenous plaque). Operators were blinded to MRI findings and used standard pre-procedural imaging. Primary outcome was ITF; secondary outcome was lesion crossing time.
Results: A total of 43 patients (86 lesions; mean age 67.5 years, 40% female) were included; 14 lesions were excluded (7 diagnostic DSA only, 7 non-diagnostic MRI). Of the 72 evaluable lesions, 66.7% were scored as soft and 33.3% were hard. ITF occurred in 15.3% of lesions, most commonly due to crossing failure (72.7%). Hard lesions had a markedly higher ITF rate compared with soft (41.7% vs 2.1%, p<0.001, Chi²=19.3). In a subgroup analysis among >75% stenosis/occlusions, ITF was 58.8% in hard vs 4.3% in soft lesions (p<0.001, Chi²=14.5). Median crossing time was significantly prolonged in hard lesions (535s vs 38s, p=0.024).
Conclusion: UTE-MRI enables in vivo characterization of vessel wall composition and predicts procedural complexity and ITF in PVI. Despite its potential, assessment of plaque morphology remains underused in CLTI care. Incorporating UTE-MRI into clinical workflows may refine patient selection, guide interventional strategy, and improve outcomes.
Funding: University Research Scholarship Programme from the source of The National Research, Development and Innovation Fund (EKÖP-2025-707)

University

Semmelweis University

Supervisor

N/A

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5733

Start

17:30

End

17:40