PhD Scientific Days 2026

Cardiovascular Medicine and Research 1.

Non-Contrast QISS MRI Outperforms Angiography in Detecting Lower-Limb Arterial Patency

Előadó neve

Dr. Csőre, Judit

Előadó munkahelye

Semmelweis University, Heart and Vascular Center

Előadó e-mail címe

csore.judit@semmelweis.hu

Az előadás címe

Non-Contrast QISS MRI Outperforms Angiography in Detecting Lower-Limb Arterial Patency

Szerző(k) neve és munkahelye

Dr. Csőre Judit¹

1: Semmelweis University, Heart and Vascular Center

Bemutatás módja

Szóbeli

Szekció

Cardiovascular Medicine and Research 1.

Összefoglaló szövege

Introduction: Chronic limb-threatening ischemia (CLTI) is often linked to chronic kidney disease (CKD), making vascular imaging in this population challenging. Digital subtraction angiography (DSA) remains the diagnostic reference standard but is invasive and requires iodinated contrast. Quiescent Interval Single Shot (QISS) MRI is a newer non-contrast-enhanced method that mitigates these risks.

Aims: This study aimed to determine whether QISS MRI identifies a greater number of patent arterial segments than DSA, and whether this advantage is most pronounced in patients with advanced CKD (stages 4/5).

Methods: Patients with CLTI who underwent both QISS MRI and DSA were included. Popliteal and infrapopliteal arteries were classified as patent or occluded across three sub-segments (e.g., AT1=proximal, AT2=mid, AT3=distal). Two blinded reviewers independently evaluated all images. Participants were stratified by GFR into <30, 30-59, ≥60 mL/min/1.73 m² groups. Primary outcome was the proportion of patent arterial segments identified by QISS compared to DSA across these GFR categories. Secondary outcomes included TASC and infrapopliteal GLASS score changes between modalities.

Results: Among 57 patients (752 vessel segments), QISS MRI demonstrated a significantly higher proportion of patent segments compared to DSA (67.2% vs 57.3%, p<0.001). Differences were significant in the <30 and ≥60 GFR groups, but not in the 30-59 group. TASC and GLASS scores were significantly downgraded using QISS MRI (mean TASC 2.2 vs 2.3, p=0.049; GLASS 2.6 vs 2.2, p<0.001).

Conclusion: QISS MRI identifies more patent vessel segments than DSA, especially in patients with advanced renal dysfunction. As earlier studies using older non-contrast MR techniques have shown comparable outcomes in bypasses to arteries visible only on MRI but not on DSA after three years, these results further support incorporating QISS MRI into routine limb-salvage assessment protocols.
Funding: University Research Scholarship Programme from the source of The National Research, Development and Innovation Fund (EKÖP-2025-707)

University

Semmelweis University

Supervisor

N/A

Kind

Szabad

Status

elfogadva

Accepted presentation method

szóbeli

Előadás fájl jóváhagyás

nem rendelkezett róla

Előadó

5733

Start

17:15

End

17:25